Work

Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis

Year: 2012

Type: review

Abstract: The protection of the brain from blood-borne toxins, proteins, and cells is critical to the brain's normal function. Accordingly, a compromise in the blood-brain barrier (BBB) function accompanies many neurologic disorders, and is tightly associated with brain inflammatory processes initiated by both infiltrating leukocytes from the blood, and activation of glial cells. Those inflammatory processes contribute to determining the severity and prognosis of numerous neurologic disorders, and can both cause, and result from BBB dysfunction. In this review we examine the role of BBB and inflammatory responses, in particular activation of transforming grown factor β (TGFβ) signaling, in epilepsy, stroke, and Parkinson's disease.

Source: Epilepsia

DOI: 10.1111/j.1528-1167.2012.03701.x

Authors: Soo Young Kim, Marion Buckwalter, Hermona Soreq, Annamaria Vezzani, Daniela Kaufer

Institutions: University of California, Berkeley, Stanford Medicine, Stanford University, Hebrew University of Jerusalem, Mario Negri Institute for Pharmacological Research

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Neurological Disorders and Stroke