Efficacy and Safety of Rituximab Treatment in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitides: Results from a German Registry (GRAID)
Year: 2012
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Rituximab (RTX) therapy is a treatment option in patients with refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV. METHODS: Clinical and safety data of patients with AAV treated with RTX were retrospectively assessed from the data of a German national registry. RESULTS: In total, 58 patients were included in this analysis (50/58 with granulomatosis with polyangiitis; 8/58 with microscopic polyangiitis who received at least 1 cycle, 17 patients who received 2 cycles, and 3 patients who received 3 cycles of RTX). Response was classified as complete and partial in 22 (40%) and in 29 cases (52.7%), respectively. Four patients (7.3%) were classified as nonresponders. CONCLUSION: RTX was well tolerated with good clinical efficacy in patients with refractory AAV.
Source: The Journal of Rheumatology
Authors: PETRA ROLL, EVA OSTERMEIER, MARION HAUBITZ, SVJETLANA LOVRIC, LEONORE UNGER, JULIA HOLLE, INA KÖTTER, JÖRG C. HENES, RAOUL BERGNER, ANDREA RUBBERT-ROTH, CHRISTOF SPECKER, HENDRIK SCHULZE-KOOPS, ULF MÜLLER-LADNER, MARTIN FLECK, GERD-RÜDIGER BURMESTER, FALK HIEPE, STEFAN HEITMANN, MARTIN ARINGER, REBECCA FISCHER-BETZ, THOMAS DÖRNER, HANS-PETER TONY
Institutions: University of Würzburg, Klinikum Fulda, Medizinische Hochschule Hannover, Krankenhaus Dresden-Friedrichstadt, Heinrich Heine University Düsseldorf, Universitätsklinikum Tübingen, University of Tübingen, Klinikum Ludwigshafen, University of Cologne, Katholisches Klinikum Essen, Ludwig-Maximilians-Universität München, Justus-Liebig-Universität Gießen, University of Regensburg, German Rheumatism Research Centre, Charité – Universitätsmedizin Berlin, Marienhospital Stuttgart, University Hospital Carl Gustav Carus, Technische Universität Dresden
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2139012475