Influenza vaccination for immunocompromised patients: summary of a systematic review and meta‐analysis
Year: 2013
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta-analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta-analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta-analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination.
DOI: 10.1111/irv.12084
Authors: Charles R Beck, Bruce C McKenzie, Ahmed B Hashim, Rebecca C Harris, Arina Zanuzdana, Gabriel Agboado, Elizabeth Orton, Laura Béchard‐Evans, Gemma Morgan, Charlotte Stevenson, Rachel Weston, Mitsuru Mukaigawara, Joanne Enstone, Glenda Augustine, Mobasher Butt, Sophie Kim, Richard Puleston, Girija Dabke, Robert Howard, Julie O'Boyle, Mary O'Brien, Lauren Ahyow, Helene Denness, Siobhan Farmer, Jose Figureroa, Paul Fisher, Felix Greaves, Munib Haroon, Sophie Haroon, Caroline Hird, Rachel Isba, David A Ishola, Marko Kerac, Vivienne Parish, Jonathan Roberts, Julia Rosser, Sarah Theaker, Dean Wallace, Neil Wigglesworth, Liz Lingard, Yana Vinogradova, Hiroshi Horiuchi, Javier Peñalver, Jonathan S Nguyen‐Van‐Tam
Institutions: University of Nottingham, World Health Organization, Bielefeld University, National Health Service, Health Protection Agency, Brighton and Sussex University Hospitals NHS Trust, Harvard University, Imperial College London, Leicestershire Partnership NHS Trust, Lancaster University, University College London, Tokyo Medical and Dental University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2139058641