Work

Dynamic Display of Bioactivity through Host–Guest Chemistry

Year: 2013

Type: article

Abstract: A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201306278

Authors: Job Boekhoven, Charles M. Rubert Pérez, Shantanu Sur, Amanda Worthy, Samuel I. Stupp

Institution: Northwestern University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Dental and Craniofacial Research

Awards: Cardiovascular Regenerative Medicine, Nanotechnology Strategies for Growth of Bones and Teeth