Year: 2011
Type: article
Abstract: The use of graphene electrodes with hydrogenated edges for solid‐state nanopore‐based DNA sequencing is proposed, and molecular dynamics simulations in conjunction with electronic transport calculations are performed to explore the potential merits of this idea. The results of the investigation show that, compared to the unhydrogenated system, edge‐hydrogenated graphene electrodes facilitate the temporary formation of H‐bonds with suitable atomic sites in the translocating DNA molecule. As a consequence, the average conductivity is drastically raised by about 3 orders of magnitude while exhibiting significantly reduced statistical variance. Furthermore, the effect of the distance between opposing electrodes is investigated and two regimes identified: for narrow electrode separation, the mere hindrance due to the presence of protruding hydrogen atoms in the nanopore is deemed more important, while for wider electrode separation, the formation of H‐bonds becomes the dominant effect. Based on these findings, it is concluded that hydrogenation of graphene electrode edges represents a promising approach to reduce the translocation speed of DNA through the nanopore and substantially improve the accuracy of the measurement process for whole‐genome sequencing.
Source: Advanced Functional Materials
Authors: Yuhui He, Ralph H. Scheicher, Anton Grigoriev, Rajeev Ahuja, Shibing Long, ZongLiang Huo, Ming Liu
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: Wenner-Gren Stiftelserna, Swedish Foundation for International Cooperation in Research and Higher Education, Carl Tryggers Stiftelse för Vetenskaplig Forskning, Ministerio de Economía y Competitividad, Vetenskapsrådet, Uppsala Universitet, National Science Fund for Distinguished Young Scholars
OpenAlex ID: W2139242575