Work

Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines

Year: 2003

Type: article

Abstract: Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.47.11.3630-3633.2003

Authors: Teresa Krakauer, Marilyn Buckley

Institution: United States Army Medical Research Institute of Infectious Diseases

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2139509969

FWCI: 1.747

Cites: 26

Cited by: 165

Related to: 10