Work

Experimental myocardial hypertrophy induced by a minimally invasive ascending aorta coarctation

Year: 2001

Type: article

Abstract: Ascending aorta coarctation was produced by a minimally invasive technique in rabbits. Animal mortality was 5%. Morphometric and hemodynamic parameters were evaluated. A parabiotically isolated heart model was used to assess the hemodynamic parameters. Left ventricular weight/body weight ratio and muscle area showed clear evidence of hypertrophy when compared to control. The hemodynamic changes in the isolated heart model suggested decreased diastolic and systolic function in the coarcted group. The present model produced hypertrophy with low mortality rates as a result of its less invasive nature.

Source: Brazilian Journal of Medical and Biological Research

DOI: 10.1590/s0100-879x2001000300017

Authors: A.S. Martins, N.W. Aguilera, B.B. Matsubara, E.A. Bregagnollo

Institution: Universidade Estadual Paulista (Unesp)

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,600