Work

Multicomponent Assembly of Highly Substituted Indoles by Dual Palladium‐Catalyzed Coupling Reactions

Year: 2012

Type: article

Abstract: Highly substituted indoles were synthesized by a palladium-catalyzed reaction involving three independent components in a one-pot reaction. Two distinct palladium-catalyzed coupling reactions occur with a single catalytic system: a Buchwald-Hartwig reaction and an arene-alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201204633

Authors: John M. Knapp, Jie S. Zhu, Dean J. Tantillo, Mark J. Kurth

Institution: University of California, Davis

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: MBRS/SCORE at York College, Complex Heterocycles and Hybrid Strategies for Pilot Scale Libraries