Work

Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis

Year: 2012

Type: review

Abstract: The therapeutic benefits of adrenocorticotropic hormone in multiple sclerosis are usually ascribed to its corticotropic actions. Evidence is presented that adrenocorticotropic hormone, approved for multiple sclerosis relapses, acts via corticosteroid-independent melanocortin pathways to engender down-modulating actions on immune-system cells and the cytokines they synthesize. Immune response-dampening effects are also brought about by agent-induced neurotransmitters that inhibit immunocytes. The likelihood that adrenocorticotropic hormone promotes microglial quiescence and counteracts glucocorticoid-mediated bone resorption is discussed.

Source: Multiple Sclerosis Journal

DOI: 10.1177/1352458512458844

Authors: Barry G Arnason, Regina Berkovich, Anna Catania, Robert P Lisak, Mone Zaidi

Institutions: University of Chicago Medical Center, University of Southern California, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Wayne State University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,400