Regulation of DNA Synthesis and Replication Checkpoint Activation During C. elegans Development
Year: 2011
Type: book-chapter
Abstract: Replication of the DNA during the synthesis (S) phase of the cell cycle is one of the most critical aspects of cell division. DNA replication must be highly accurate and tightly controlled to maintain genomic integrity over many rounds of cell division. This is particularly important during animal development, since genetic instability can lead to cell death, birth defects, developmental abnormalities and diseases such as cancer. The developmental context also adds specific constraints to S-phase regulation. For instance, variations in DNA replication control are needed to accommodate the rapid embryonic divisions in early embryos, the production of haploid germ cells, and the generation of polyploid tissues. A comprehensive understanding of DNA replication requires insight in these developmental aspects of S phase control. Here, we review the initiation of DNA replication in the genetic animal model Caenorhabditis elegans (C. elegans), with a focus on developmental-stage and tissue-specific regulation.
Source: InTech eBooks
DOI: 10.5772/19397
Institution: Utrecht University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2140054596