Year: 2013
Type: article
Abstract: The two classical forms of human trypanosomoses are sleeping sickness due to Trypanosoma brucei gambiense or T. brucei rhodesiense, and Chagas disease due to T. cruzi. However, a number of atypical human infections caused by other T. species (or sub-species) have been reported, namely due to T. brucei brucei, T. vivax, T. congolense, T. evansi, T. lewisi, and T. lewisi-like. These cases are reviewed here. Some infections were transient in nature, while others required treatments that were successful in most cases, although two cases were fatal. A recent case of infection due to T. evansi was related to a lack of apolipoprotein L-I, but T. lewisi infections were not related to immunosuppression or specific human genetic profiles. Out of 19 patients, eight were confirmed between 1974 and 2010, thanks to improved molecular techniques. However, the number of cases of atypical human trypanosomoses might be underestimated. Thus, improvement, evaluation of new diagnostic tests, and field investigations are required for detection and confirmation of these atypical cases.
Source: PLoS neglected tropical diseases
Institutions: Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut de Recherche pour le Développement, Instituut voor Tropische Geneeskunde, Universidad Simón Bolívar, World Health Organization, Government Medical College, Indira Gandhi Government Medical College & Hospital, Guru Angad Dev Veterinary and Animal Sciences University, Sun Yat-sen University, Food and Agriculture Organization of the United Nations, Université Libre de Bruxelles, Universidade de São Paulo, Organisation Mondiale de la Santé Animale, Université de Bordeaux, Kasetsart University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,670
OpenAlex ID: W2140941348