Work

Development of Histone Deacetylase Inhibitors as Therapeutics for Neurological Disease

Year: 2009

Type: article

Abstract: Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states are associated with several neurological and neuromotor diseases. Thus, small molecules that inhibit or activate the enzymes responsible for these chromatin modifications have received considerable attention as potential human therapeutics. This paper summarizes the current state of development of histone deacetylase inhibitors in a variety of neurological diseases.

Source: Future Neurology

DOI: 10.2217/fnl.09.55

Authors: Joel M Gottesfeld, Massimo Pandolfo

Institutions: Scripps Research Institute, Université Libre de Bruxelles, Erasmus Hospital

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke