Work

The two faces of DNA repair: disease and therapy.

Year: 2013

Type: article

Abstract: Our genome is the blueprint for our bodies. A number of sophisticated mechanisms help protect our genome from life-threatening cellular mistakes and environmental insults. Much current research focuses on understanding these mechanisms, how they prevent disease, and whether they can be targeted for therapeutic purposes. Here, we review the main mechanisms maintaining genome integrity, how their malfunctioning results in disease, and the exciting progress toward targeting these mechanisms for cancer treatments.

Source: Europe PMC (PubMed Central)

Authors: Alessandro Vindigni, Susana Gonzalo

Institution: Saint Louis University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: MECHANISMS RESPONSIBLE FOR GENOMIC INSTABILITY IN PREMATURE AGING LAMINOPATHIES