Work

Contribution of CD8+T Cells to Containment of Viral Replication and Emergence of Mutations inMamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Year: 2008

Type: article

Abstract: Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.

Source: Journal of Virology

DOI: 10.1128/jvi.02749-07

Authors: Eun-Young Kim, Ronald S. Veazey, Roland Zahn, Kimberly J. McEvers, Susanne H. C. Baumeister, Gabriel J. Foster, Melisa D. Rett, Michael H. Newberg, Marcelo J. Kuroda, E. Peter Rieber, Michael Piatak, Jeffrey D. Lifson, Norman L. Letvin, Steven M. Wolinsky, Jörn E. Schmitz

Institutions: Northwestern University, Tulane University, Beth Israel Deaconess Medical Center, Technische Universität Dresden, National Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Center for AIDS Research, University of Washington, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Research Resources

Awards: G126306927, G1356092923, High Resolution Structural Studies dsDNA Bacteriophage, DCTD Computer Support, G1799052500, G2149684344, G2407652348, Resource for Nonhuman Primate Cell Depleting Antibodies, Immunoregulation in AIDS, G3277247684, G3778511969, G4166928756, Immune control of SIVagm replication in vivo, G7350712540, CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS, IMMUNOREGULATION IN AIDS, G9000129761, Harvard University Center for AIDS Research

OpenAlex ID: W2145001217

FWCI: 1.458

Cites: 18

Cited by: 23

Related to: 10