Year: 1976
Type: article
Abstract: The close association of biochemical methods and high resolution of electron microscopy has introduced a new pathology, the biochemical pathology of cell organelles, a new field of study in which the structure of the altered cell organelles and their altered function can be elucidated. In this respect, electron microscopy has bridged the gap between morphology and function, or in other words, between light microscopy and biochemistry. The electron microscope is successfully used at present as a fundamental tool in the analysis of subcellular changes induced by drugs and other agents, thus adding a new dimension to the evaluation of drug safety at the ultrastruc-turai level. It is now possible, with the high resolution of the electron microscope, to demonstrate early phases of cell injury long before they are detected in the light microscope,
Author: F. George Zaki
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2145368449