Do some of the newer COX-2 inhibitors cross-react with sulfonamide antibiotics? An overview
Year: 2011
Type: article
Abstract: The professional information leaflets of three locally available specific cyclooxygenase-2 inhibitors indicate that these \ndrugs are contraindicated in persons with a known allergy to sulfonamides. There are many concerns about cross-allergenicity \nbetween sulfonamide antibiotics and non-antibiotic sulfonamide-containing drugs including the sulfones, and \nthese concerns continue to complicate drug therapy. Several elegant investigations have demonstrated lack of interaction \nbetween the sulfonamide group and either cellular or humoral immunity. The immunologic determinant of type I \nimmunologic responses to sulfonamide antibiotics are the N1 heterocyclic ring, and non-antibiotic sulfonamides \nincluding the sulfones lack this structural feature. Reactive sulfonamide metabolites contribute many non-type I hypersensitivity \nresponses to sulfonamide antibiotics. Metabolite formation demonstrates stereospecificity to the N4 amino \nnitrogen of the sulfonamide antibiotics, a structure not found on any non-antibiotic sulfonamide drugs and is also lacking \nin the sulfones. Apparent cross-reactivity responses to sulfonamide-containing drugs likely represent multiple concurrent, \nrather than linked, drug hypersensitivities.
Author: George L. Muntingh
Institution: University of Pretoria
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2145897012