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Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs

Year: 2015

Type: article

Abstract: A novel approach for developing prodrugs based on masked carboxylic acids is described. Rather than using conventional esterase-based activation, thiazolidinone protecting groups have been identified that can reveal carboxylic acid groups upon activation by hydrogen peroxide. This may prove valuable in the continuing development of prodrug strategies that rely on reactive oxygen species (ROS) as a trigger.

Source: Chemical Communications

DOI: 10.1039/c4cc09921d

Authors: Christian Perez, Jean-Philippe Monserrat, Yao Chen, Seth M. Cohen

Institution: University of California San Diego

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, University of California, San Diego, National Institute of General Medical Sciences

Award: Insight and Optimization of Metalloprotein Inhibitors