Work

Origins of Microsatellite Diversity in the Trichophyton rubrum - T. violaceum Clade (Dermatophytes)

Year: 2004

Type: article

Abstract: We analyzed the population structure of the anthropophilic dermatophyte species Trichophyton violaceum, which mainly causes tinea capitis, and T. rubrum, the most frequently isolated agent of dermatophytosis worldwide. A microsatellite marker (T1) was developed by using the enrichment technique for microsatellites. The T1 marker containing a (GT)(8-10) repeat was proven to specifically amplify both species, underlining their close kinship. Four polymorphic alleles were detected within a set of about 130 strains by using polyacrylamide gel electrophoresis with this marker. An association with geographic origin of the isolates was apparent. Given the close relatedness of both species, these data suggest an African origin of the entire T. rubrum complex, followed by the emergence of a new genotype (B) in Asia with subsequent spread of this genotype over Europe and the United States.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.42.10.4444-4448.2004

Authors: T. Ohst, S. de Hoog, W. Presber, V. Stavrakieva, Y. Gräser

Institutions: Humboldt-Universität zu Berlin, Charité – Universitätsmedizin Berlin, Westerdijk Fungal Biodiversity Institute, National Center of Infectious and Parasitic Diseases

Language: English

Topic: Nail Diseases and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2147403288

FWCI: 3.595

Cites: 15

Cited by: 82

Related to: 10