Work

Age‐Dependent Decrease in Serum Transforming Growth Factor (TGF)‐Beta 1 in Healthy Japanese Individuals; Population Study of Serum TGF‐Beta 1 Level in Japanese

Year: 2005

Type: article

Abstract: Transforming growth factor-beta1 (TGF-beta1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-beta1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF-beta1 level in pediatric patients. The diagnostic application of the measurement of serum TGF-beta1 level depends critically on the control value, however, there is no information on the control value of serum TGF-beta1 for children. In the present study, we determined the serum TGF-beta1 level of healthy Japanese children as a control value with enzyme-linked immunosorbent assay (ELISA). The serum TGF-beta1 level of children (0-14 years old) was significantly higher than that of adults (over 15 years old) (p < 0.01). Thus, it is recommended that when the serum TGF-beta1 levels of patients are evaluated, they should be compared with those of age-matched controls.

Source: Disease Markers

DOI: 10.1155/2005/381215

Authors: Yoshihiro Okamoto, Yoshimitsu Gotoh, Osamu Uemura, Soichi Tanaka, Tsunesaburo Ando, Mikio Nishida

Institutions: Meijo University, Japanese Red Cross Nagoya Daini Hospital, Komaki City Hospital

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,550