Antioxidant activity and anticarcinogenic properties of rumput mutiara {Hedyotis corymbosa (L.) Lam.} and pohpohan {Pilea trinervia (Roxb.) Wight}
Year: 2011
Type: article
Abstract: The research was conducted to determine the anticarcinogenic properties of “rumput mutiara” (Hedyotis corymbosa (L.) Lam) and “pohpohan” (Pilea trinervia (Roxb.) Wight), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependent-hormone (MCF-7) cell lines. The preliminary results showed that the “rumput mutiara” extract displayed the cytotoxic effects against MCF-7 with IC50-value of 22,67 µg/ml. However, the “pohpohan” extract did not show the IC50-value against MCF-7 cell lines. The antioxidative activities of the extracts which could contribute to their cytotoxic properties were also studied. The “rumput mutiara” extract was found to have higher antioxidant activity compared with “pohpohan” extract. The strong cytotoxic properties of the “rumput mutiara” extract could be due to its high antioxidant activity.
Key words: Microculture tetrazolium salt assay, Hedyotis corymbosa, Pilea trinervia, MCF-7, antioxidant activity, cytotoxic properties.
DOI: 10.5897/jmpr.9000192
Author: Susi Endrini
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2152009983