Work

FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604: II. Biological Activities

Year: 2004

Type: article

Abstract: Novel cholesterol synthesis inhibitors FR171456 and FR173945 were isolated from the culture broth of Sporormiella minima No. 15604. FR171456 strongly inhibited the cholesterol synthesis and up-regulated the LDL-receptor expression in human hepatoma cell line Hep G2. Single oral administration of FR171456 inhibited in vivo hepatic sterol synthesis in rats. And FR171456 shows a significant serum cholesterol-lowering effect in a cholesterol fed rabbit model.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.57.260

Authors: HIDETAKA HATORI, TOSHIHIRO SHIBATA, MOTOAKI NISHIKAWA, HIROTSUGU UEDA, MOTOHIRO HINO, TAKASHI FUJII

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2152306751

FWCI: 0.464

Cites: 6

Cited by: 8

Related to: 10