Work

Direct Synthesis of 5‐Aryl Barbituric Acids by Rhodium(II)‐Catalyzed Reactions of Arenes with Diazo Compounds

Year: 2015

Type: article

Abstract: A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free N-H groups are tolerated on the barbituric acid, with no complications arising from N-H insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201502324

Authors: Daniel Best, David J. Burns, Hon Wai Lam

Institution: University of Nottingham

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Engineering and Physical Sciences Research Council

Awards: G1080175765, Increasing the Efficiency of Chemical Synthesis Using Asymmetric Transition Metal Catalysis