Work

Aconitate hydratase of mammals under oxidative stress

Year: 2008

Type: review

Abstract: Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.

Source: Biochemistry (Moscow)

DOI: 10.1134/s0006297908090010

Authors: L. V. Matasova, T. N. Popova

Institution: Voronezh State University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Ministry of Education and Science of the Russian Federation

OpenAlex ID: W2154136263