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A Highly Flexible Dinuclear Ruthenium( II )–Platinum( II ) Complex: Crystal Structure and Binding to 9‐Ethylguanine

Year: 2004

Type: article

Abstract: The length and high flexibility of the linker in a heterodinuclear ruthenium–platinum complex (see X-ray crystal structure) enables the platinum unit to independently interact with DNA by π–π stacking or coordination, possibly after pre-association of the 2+ charged ruthenium unit. A prototype of this challenging class of potentially cytostatic compounds is presented.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200460319

Authors: Karlijn van der Schilden, Fedora Garcìa, Huub Kooijman, Anthony L. Spek, Jaap G. Haasnoot, Jan Reedijk

Institutions: Leiden University, Utrecht University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2154244708

FWCI: 5.881

Cites: 18

Cited by: 99

Related to: 10