Work

Wolbachia- andOnchocerca volvulus-Induced Keratitis (River Blindness) Is Dependent on Myeloid Differentiation Factor 88

Year: 2006

Type: article

Abstract: Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.

Source: Infection and Immunity

DOI: 10.1128/iai.74.4.2442-2445.2006

Authors: Illona Gillette-Ferguson, Amy G. Hise, Yan Sun, Eugenia Diaconu, Helen F. McGarry, Mark J. Taylor, Eric Pearlman

Institutions: Case Western Reserve University, University of Liverpool, Liverpool School of Tropical Medicine

Language: English

Topic: Parasitic Diseases Research and Treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, National Eye Institute, National Institute of Allergy and Infectious Diseases

Awards: Innate immune responses in lymphatic filariasis, G34086324, Training in Geographic Medicine and Infectious Diseases, The Role of Wolbachia Endobacteria in River Blindness, CWRU NEI Vision Center Core Grant

OpenAlex ID: W2154514435

FWCI: 2.757

Cites: 24

Cited by: 32

Related to: 10