Work

Phenotypic Detection of Carbapenemase-Producing Enterobacteriaceae by Use of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and the Carba NP Test

Year: 2014

Type: article

Abstract: We compared the diagnostic accuracy of the Carba NP test with that of a straightforward matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method for detecting carbapenemase-producing Enterobacteriaceae (CPE). Using PCR as the reference method, both tests demonstrated a sensitivity of 87% and a specificity of 100%. MALDI-TOF MS offers a potential alternative for the rapid detection of CPE in the clinical laboratory setting.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.02121-14

Authors: James Knox, Snehal Jadhav, Danielle Sevior, Alex Agyekum, Margaret Whipp, Lynette Waring, Jonathan Iredell, Enzo Palombo

Institutions: Swinburne University of Technology, The University of Sydney, The University of Melbourne, Westmead Hospital

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2155195361

FWCI: 5.737

Cites: 16

Cited by: 56

Related to: 10