Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
Year: 2015
Type: review
Abstract: As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Source: Carcinogenesis
Authors: Rita Nahta, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah N. Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen-Solal, Anna Maria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte, Gary S. Goldberg, Roslida A. Hamid, Harini Krishnan, Dale W. Laird, Ahmed Lasfar, Paola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondráček, Mark Wade, Jordan Woodrick, William H. Bisson
Institutions: Dalhousie University, Emory University, Kuwait University, Winship Cancer Institute, University of Florence, Columbia University, Colorado State University, Colorado School of Public Health, University of Tarapacá, Columbia University Irving Medical Center, Children's Healthcare of Atlanta, Rutgers Cancer Institute, Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University Medical Center, University of Palermo, Rowan University, Universiti Putra Malaysia, Western University, Rutgers, The State University of New Jersey, Istituto di Genetica Molecolare, National Research Council, University of British Columbia, Health Canada, City University of New York, Georgetown University Medical Center, Georgetown Lombardi Comprehensive Cancer Center, Cairo University, Cairo University hospitals, King George's Medical University, Temple University, Czech Academy of Sciences, Institute of Biophysics, Italian Institute of Technology, Center for Genomic Science, Oregon State University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mechanisms of PPM1D in medulloblastoma tumorigenesis and invasion, DNA Repair of Endogenous Lesions in Carcinogenesis, The Halifax Project: Chemical Mixtures and Cancer, Mechanisms of Herceptin resistance, Regulations of DNA Alkylation/Deamination Damage Repair, Pemetrexed and sildenafil for lung cancer, Training Grant In Tumor Biology
OpenAlex ID: W2156567043