Work

A retrospective clinicopathological study on oral lichen planus and malignant transformation: Analysis of 518 cases

Year: 2012

Type: article

Abstract: OBJECTIVE: To investigate the epidemiological and clinical characteristics of a relatively large cohort of patients with oral lichen planus (OLP) from eastern China. STUDY DESIGN: A total of 518 patients with histologically confirmed OLP in a long-term follow-up period (6 months-21.5 years) were retrospectively reviewed in our clinic. RESULTS: Of the 518 patients, 353 females and 165 males were identified. The average age at diagnosis was 46.3 years (range 9-81 years) with the buccal mucosa being the most common site (87.8%). At initial presentation, white lichen and red lichen was seen in 52.3% and 47.7% patients, respectively. Of these, 5 (0.96%) patients previously diagnosed clinically and histopathologically as OLP developed oral cancer. All of them were the females with no a history of smoking or alcohol use. CONCLUSIONS: Clinical features of eastern Chinese OLP patients were elucidated. Notably, approximately 1% of OLP developed into cancer, which provides further evidence of potentially malignant nature of OLP.

Source: Medicina oral, patología oral y cirugía bucal

DOI: 10.4317/medoral.17778

Authors: ZY. Shen, W. Liu, LK. Zhu, JQ. Feng, GY. Tang, ZT. Zhou

Institutions: Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Jilin University

Language: Spanish

Topic: Oral Health Pathology and Treatment

Subfield: General Dentistry

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Shanghai Leading Academic Discipline Project