Work

Combined Use of Mycobacterium tuberculosis–Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis

Year: 2014

Type: article

Study design: Observational Study

Abstract: Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciu795

Authors: Virginie Rozot, Amelio Patrizia, Selena Vigano, Jesica Mazza-Stalder, Elita Idrizi, Cheryl L. Day, Matthieu Perreau, Catherine Lazor-Blanchet, Khalid Ohmiti, Delia Goletti, Pierre-Alexandre Bart, Willem Hanekom, Thomas J. Scriba, Laurent Nicod, Giuseppe Pantaleo, Alexandre Harari

Institutions: University of Cape Town, Centre Hospitalier Universitaire Vaudois, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Lausanne, Swiss Vaccine Research Institute

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,763

Funders: Wellcome Trust, European Commission, Centre Hospitalier Universitaire Vaudois, Swiss Vaccine Research Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Mechanisms of Immune Regulation in Mycobacterium Tuberculosis Infection, Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative, G76681233, Emory National Primate Research Center

OpenAlex ID: W2157465331

FWCI: 5.965

Cites: 21

Cited by: 82

Related to: 10