Year: 2014
Type: article
Abstract: Terpenes are the most promising natural chemical enhancers used to amplify the transdermal permeation of drugs, among them monoterpenes and sesquiterpenes have been widely suggested.Permeation enhancement effect of various terpenes (nerolidol, farnesol, limonene, linalool, menthol, geraniol, carvone, fenchone etc.) in various combinations of preparations on ibuprofen (IBU) and its solid dispersions (IBUSD1) from Carbopol 941 gel formulations (0.9 %) were studied.Skin permeation studies and release kinetics have shown farnesol (2.5 and 5 %) and geraniol (2.5 %) had the best permeation enhancement on the release rate of ibuprofen gel.Limonene (2.5 %), geraniol (2.5 and 5 %) had the best permeation enhancement on the release rate of ibuprofen solid dispersion gel.Ex-vivo studies of ibuprofen gel revealed that farnesol with highest lipophilicity (log P 5.31) significantly (p < 0.0001) increased the flux and permeability coefficient compared to control, with a flux rate of 605.6 μg/cm 2 /hr and permeability coefficient of 6.2 cm/h.Studies of ibuprofen solid dispersion gel revealed that limonene with highest lipophilicity (log P 4.58) significantly (p < 0.0001) increased the flux and permeability coefficient compared to control with a flux rate of 738.6 μg/cm 2 /h and permeability coefficient of 8.86 cm/h.Rank order of enhancement effect in terms of boiling point of terpenes for ibuprofen gel was farnesol (111 o C) > geraniol (230 o C) and that of ibuprofen solid dispersion gel was limonene (176 o C) > geraniol (230 o C).All optimized formulations obeyed the Higuchi release kinetics and non fickian type of diffusion.
Authors: Rajitha K, Lakshmi P K, Pranitha Akula, Prasanthi D
Institution: G. Pulla Reddy College of Pharmacy
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2160220616