Work

Initiating Insulin Therapy in Type 2 Diabetic Patients Failing on Oral Hypoglycemic Agents

Year: 2009

Type: article

Abstract: T ype 2 diabetes is a chronic diseasecharacterized by coexisting insulindeficiency and insulin resistance, with the resultant hyperglycemia leading to micro- and macrovascular complica-tions. A large number of intervention tri-als demonstrated that improving glycemic control achieves considerable reductions of such complications (1–7). It has been estimated using the ho-meostasis multiple assessment (HOMA) that, at the time of diagnosis, 50 % of pancreatic -cell function has been lost, with almost 4 % further loss of function expected per year thereafter (8,9). There-fore, type 2 diabetes is a chronic progres-sive disease characterized by worsening

Source: Diabetes Care

DOI: 10.2337/dc09-s319

Authors: Reinhard G. Bretzel, Michael Eckhard, Wolfgang Landgraf, David R. Owens, Thomas Linn

Institutions: Universitätsklinikum Gießen und Marburg, Sanofi (Germany), University Hospital Llandough

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid