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OL-045 Hepatocyte growth factor promotes liver regeneration induced by transfusion of bone marrow mononuclear cells in a murine acute liver failure model

Year: 2010

Type: conference-abstract

Abstract: Background: Bone marrow mononuclear cells (BMMCs) transplantation is a potential therapy for acute liver failure; however, its therapeutic efficacy requires improvement.Methods: We established a murine acute liver failure model induced by CCl4 administration.The effect of BMMCs transplantation in combination with hepatocyte growth factor (HGF) was studied.Recipient mice were transfused with PKH26-labeled BMMCs (5×10 6 ) with HGF (50 ng/kg.d×7 days) (BMMCs + HGF group).BMMCs only, HGF alone, and 0.9% NaCl alone were included as control groups.To assess the effect of donor BMMCs in liver regeneration, quantitative image analysis with immunohistochemistry for PKH26, proliferating cell nuclear antigen (PCNA), and albumin expression was performed after transplantation.

Source: International Journal of Infectious Diseases

DOI: 10.1016/s1201-9712(10)60056-2

Authors: S.-Z. Jin, X.-W. Meng, X. Sun, M.-Z. Han, B.-R. Liu, X.-H. Wang, F.-H. Pei

Institutions: Jilin University, First Hospital of Jilin University, Harbin Medical University, Second Affiliated Hospital of Harbin Medical University

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900

OpenAlex ID: W2163333645

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