Work

New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

Year: 2005

Type: article

Abstract: Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.

Source: Journal of the Brazilian Chemical Society

DOI: 10.1590/s0103-50532005000800029

Authors: Geraldo H. Silva, Helder L. Teles, Henrique C. Trevisan, Vanderlan da S. Bolzani, Maria C. M. Young, Ludwig H. Pfenning, Marcos N. Eberlin, Renato Haddad, Claudio M. Costa-Neto, Ângela R. Araújo

Institutions: Universidade Estadual Paulista (Unesp), Instituto de Botânica, Universidade Federal de Lavras, Universidade Estadual de Campinas (UNICAMP), Universidade de São Paulo

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $275

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico

Award: Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II

OpenAlex ID: W2163370355

FWCI: 0.931

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Cited by: 73

Related to: 10