Work

Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy

Year: 1989

Type: article

Abstract: Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N-acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic acid to about 16 mM within the lesion, indicating continued anaerobic glycolysis. The diluting effect of the edema has been estimated to reduce average metabolite concentrations by about a factor of 3.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.1910090115

Authors: H. Bruhn, J. Frahm, M. L. Gyngell, K. D. Merboldt, W. Hänicke, R. Sauter

Institutions: Max Planck Institute for Biophysical Chemistry, Siemens (Germany)

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Bundesministerium für Forschung und Technologie