Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China
Year: 2009
Type: article
Study design: Observational Study
Abstract: The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg(+)) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg(+) donors, carriers with OBIs versus HBsAg(+) asymptomatic carriers, and carriers with OBIs versus HBsAg(+) chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.
Source: Journal of Clinical Microbiology
DOI: 10.1128/jcm.01781-09
Authors: Quan Yuan, Shan-Hai Ou, Chang-Rong Chen, Sheng-Xiang Ge, Bin Pei, Qing-Rui Chen, Qiang Yan, Yong-Cai Lin, Hong-Ying Ni, Cheng-Hao Huang, Anthony E. T. Yeo, James W. K. Shih, Jun Zhang, Ning-Shao Xia
Institutions: Xiamen University, Xiamen Blood Center
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2166689028