Work

SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism

Year: 2013

Type: article

Abstract: An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions.

Source: Genome Integrity

DOI: 10.1186/2041-9414-4-6

Authors: Augustin Luna, Mirit I Aladjem, Kurt W Kohn

Institutions: Boston University, National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: Ford Foundation, National Institutes of Health, National Cancer Institute

OpenAlex ID: W2167253239

FWCI: 2.642

Cites: 119

Cited by: 94

Related to: 10