Work

Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals

Year: 2007

Type: article

Abstract: Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.

Source: Química Nova

DOI: 10.1590/s0100-40422007000200029

Authors: Marta Maria Duarte Carvalho Vila, Robson Machado de Oliveira, Marcos Moisés Gonçalves, Matthieu Tubino

Institutions: Universidade de Sorocaba, Universidade Estadual de Campinas (UNICAMP)

Language: English

Topic: Analytical Methods in Pharmaceuticals

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $330