Work

Synthesis and characterization of thermo-responsive particles of poly(hydroxybutirate-co-hydroxyvalerate)-b-poly(N-isopropylacrylamide)

Year: 2009

Type: article

Abstract: A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system.

Source: Brazilian Journal of Physics

DOI: 10.1590/s0103-97332009000200015

Authors: Adriano Marim de Oliveira, Pedro Carlos de Oliveira, Amilton Martins dos Santos, Maria Helena Ambrosio Zanin, Maria Inês Ré

Institutions: Universidade de São Paulo, Instituto de Pesquisas Tecnológicas

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,290

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Centre National de la Recherche Scientifique