Work

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Year: 2015

Type: article

Abstract: Etoposide phosphate (EP), a water-soluble anticancer prodrug, is widely used for treatment of many cancers. After administration it is rapidly converted to etoposide, its parent compound, which exhibits anticancer activity. Difficulty in parenteral administration necessitates the development of a suitable nanoparticle delivery system for EP. Here we have used indium both as a carrier to deliver etoposide phosphate to tumor cells and as a SPECT imaging agent through incorporation of (111)In. Etoposide phosphate was successfully encapsulated together with indium in nanoparticles, and exhibited dose dependent cytotoxicity and induction of apoptosis in cultured H460 cancer cells via G2/M cell cycle arrest. In a mouse xenograft lung cancer model, etoposide phosphate/indium nanoparticles induce tumor cell apoptosis, leading to significant enhancement of tumor growth inhibition compared to the free drug.

Source: Nanoscale

DOI: 10.1039/c5nr04509f

Authors: Ramishetti Srinivas, Andrew Satterlee, Yuhua Wang, Yuan Zhang, Yongjun Wang, Leaf Huang

Institutions: University of North Carolina at Chapel Hill, North Carolina State University, Lampe Joint Department of Biomedical Engineering

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Cancer Institute