Fruits and vegetables and renal cell carcinoma: Findings from the European prospective investigation into cancer and nutrition (EPIC)
Year: 2006
Type: article
Study design: Observational Study
Abstract: We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation.
Source: International Journal of Cancer
DOI: 10.1002/ijc.21765
Authors: Steffen Weikert, Heiner Boeing, Tobias Pischon, Anja Olsen, Anne Tjonneland, Kim Overvad, Nikolaus Becker, Jacob Linseisen, Petra H. Lahmann, Athina Arvaniti, Christina Kassapa, Antonia Trichoupoulou, Sabina Sieri, Domenico Palli, Rosario Tumino, Paolo Vineis, Salvatore Panico, Carla H. van Gils, Petra H. M. Peeters, H. Bas Bueno‐de‐Mesquita, Frederike L. Büchner, Börje Ljungberg, Göran Hallmans, Göran Berglund, Elisabet Wirfält, Guillem Pera, Miren Dorronsoro, Aurelio Barricarte Gurrea, Carmen Navarro, Carmen Martinez, J. Ramón Quirós, Naomi Allen, Andrew Roddam, Sheila Bingham, Mazda Jenab, Nadia Slimani, Teresa Norat, Elio Riboli
Institutions: German Institute of Human Nutrition, Charité – Universitätsmedizin Berlin, Danish Cancer Society, Aalborg University Hospital, Aarhus University Hospital, German Cancer Research Center, National and Kapodistrian University of Athens, University of Turin, University of Naples Federico II, University Medical Center Utrecht, National Institute for Public Health and the Environment, Umeå University, Lund University, Institut Català d'Oncologia, Instituto de Salud Pública de Navarra, Andalusian School of Public Health, Gobierno del Principado de Asturias, Cancer Research UK, University of Oxford, MRC Mitochondrial Biology Unit, Medical Research Council, Centre international de recherche sur le cancer
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Compagnia di San Paolo, Deutsches Krebsforschungszentrum, Wellcome Trust, Cancer Research UK, British Heart Foundation, Stroke Association, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Deutsche Krebshilfe, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
Award: G2068095830
OpenAlex ID: W2170050145