Year: 2013
Type: article
Abstract: The current study was designed to prepare and characterize insulin incorporated nanoparticles by complex coacervation process followed by antidiabetic study of orally administered insulin incorporated nanoparticles in diabetic rats. The nanoparticles were characterized for particle size, loading and entrapment efficiency as well as in vitro release of incorporated insulin. The prepared nanoparticles were found to have an average particle size of 551.67 nm ±45.5 . The highest entrapment efficiency and loading capacity values were found to be of 52.48±1.98 and 47.01±1.21 , respectively. Oral administration of 10 IU/Kg of insulin loaded nanoparticles to diabetic rats showed a maximum blood glucose change of 53.46±2.19 at 5-hours time period. The results obtained indicate the potential of prepared nanoparticulate system as a carrier for oral delivery of insulin.
Source: ISRN Nanotechnology
DOI: 10.1155/2013/591751
Authors: Amiya kumar Prusty, Susanta Kumar Sahu
Institutions: Institute of Pharmacy & Technology, Salipur, Utkal University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2172103188