Work

YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties.

Year: 2003

Type: article

Abstract: Novel antibiotics, YM-266183 (1) and YM-266184 (2), were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica. The structures of both antibiotics were determined by several spectroscopic experiments as new thiopeptide compounds. They exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains, whereas they were inactive against Gram-negative bacteria.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.56.123

Authors: KOJI NAGAI, KAZUMA KAMIGIRI, NAKAKO ARAO, KEN-ICHI SUZUMURA, YASUHIRO KAWANO, MASAKAZU YAMAOKA, HUIPING ZHANG, MASATO WATANABE, KENICHI SUZUKI

Institutions: National Institute of Advanced Industrial Science and Technology, Fudan University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: Ministry of Economy, Trade and Industry

OpenAlex ID: W2180677481

FWCI: 2.432

Cites: 17

Cited by: 78

Related to: 10