Work

Mechanisms of the cytotoxicity of carbon nanotubes

Year: 2011

Type: article

Abstract: Probable mechanisms of cytotoxicity of a total fraction of multi-walled carbon nanotubes using spin probe methods (in human erythrocytes and rat hepatocytes) and electrical breakdown (in mouse oocytes) have been studied. Erythrocyte membrane damage induced by carbon nanotubes is developed in time. After two-day exposure at 279 K the erythrocyte samples with carbon nanotubes concentrations of 10, 50, 100, and 200 ?g / ml showed a part of damaged erythrocytes of 4, 10, 16, and 25%, respectively. A 4 h exposure of rat liver homogenate with carbon nanotubes at 273 K resulted in a significant decrease in liver homogenate mitochondrial activity. The study of the processes of oocyte electroporation has shown that probable mechanisms of nanotube cytotoxicity are associated with an increase in membrane conductivity, alteration of surface potential, formation of defects within the membrane, and as a consequence, with an increase in membrane permeability. In addition to their capability to affect membrane structural changes, the nanotubes have a capacity to inhibit delicate electrochemical processes in cells.

Source: Himia Fizika ta Tehnologia Poverhni

Authors: Kartel, M. T., Chernykh, V. P., Ivanov, L. V., Gordienko, E. A., Kovalenko, S. N., Gubin, Yu. I., Nardid, O. A., Smolyaninova, E. I.

Institutions: Chuiko Institute of Surface Chemistry, National University of Pharmacy, National Academy of Sciences of Ukraine, Institute for Problems of Cryobiology and Cryomedicine

Language: English

Topic: Graphene and Nanomaterials Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2182118934

FWCI:

Cites: 10

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Related to: 10