Work

Anti-allergic activity of compounds from Boesenbergia thorelii

Year: 2013

Type: article

Abstract: Boesenbergia thorelii extract of rhizomes and its compounds were investigated for anti-allergic activities usingantigen-induced -hexosaminidase release in RBL-2H3 cells. From bioassay-guided fractionation, the chloroform fraction wasseparated to afford four compounds: asaronaldehyde (1), -sitosterol-D-glucoside (2), protocatechuic acid methyl ester (3)and 2-hydroxy-1-(3, 4-dimethoxyphenyl) ethanols (4). Their structures were elucidated on the basis of UV, IR and NMRspectroscopic data. Of these, compound 1 (asaronaldehyde) was the most active with an IC50 value of 24.3 µM, followed by2 (IC50 = 63.3 µM) and 4 (IC50 = 72.6 µM); whereas compound 3 was inactive (IC50 > 100µM). Anti-allergic effect of 1 (IC50 =24.3 µM) was higher than that of ketotifen fumarate (IC50 = 41.1 µM), the positive control. This study may support the useof B. thorelii for treatment of allergy-related diseases. Moreover, this is the first report on biological study and chemicalconstituents of B. thorelii.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Supinya Tewtrakul, Fameera Madaka, Chatchai Wattanapiromsakul, Teeratad Sudsai

Language: English

Topic: Ginger and Zingiberaceae research

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2183991122

FWCI:

Cites: 16

Cited by: 2

Related to: 10