Work

Modeling Combinations of Pre-erythrocytic Plasmodium falciparum Malaria Vaccines

Year: 2015

Type: article

Abstract: Despite substantial progress in the control of Plasmodium falciparum infection due to the widespread deployment of insecticide-treated bed nets and artemisinin combination therapies, malaria remains a prolific killer, with over half a million deaths estimated to have occurred in 2013 alone. Recent evidence of the development of resistance to treatments in both parasites and their mosquito vectors has underscored the need for a vaccine. Here, we use a mathematical model of the within-host dynamics of P. falciparum infection, fit to data from controlled human malaria infection clinical trials, to predict the efficacy of co-administering the two most promising subunit vaccines, RTS,S/AS01 and ChAd63-MVA ME-TRAP. We conclude that currently available technologies could be combined to induce very high levels of sterile efficacy, even in immune-naive individuals.

Source: American Journal of Tropical Medicine and Hygiene

DOI: 10.4269/ajtmh.14-0767

Authors: Andrew S. Walker, José Lourenço, Adrian V. S. Hill, Sunetra Gupta

Institutions: University of Oxford, Jenner Institute

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Estimated APC paid: $2,370