Work

Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

Year: 2015

Type: article

Abstract: Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.

Source: Marine Drugs

DOI: 10.3390/md14010001

Authors: Javier García-Vilas, Beatriz Martínez-Poveda, Ana Quesada, Miguel Medina

Institutions: Centre for Biomedical Network Research on Rare Diseases, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga

Language: English

Topic: Marine Sponges and Natural Products

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499