Insulin-dependent Synthesis of Liver Glucokinase in the Rat
Year: 1963
Type: article
Abstract: A glucokinase qualitatively and quantitatively adequate as \nthe first and limiting step in the synthesis of glycogen from glucose has been recently identified in the liver of the normal fed \nrat. In contrast with hexokinase, glucokinase activity was \nfound to disappear in fasted and alloxan-diabetic animals (1). \nA characteristic shared by deprivation of food and diabetes is \nthe marked decrease of insulin secretion and a very low level of \nfree insulin in plasma (2, 3). Insulin could control either the \nactivity of the glucokinase or its synthesis. The results here \ndescribed suggest that the synthesis of the enzyme is insulin-dependent. No hormonal effect on its activity has been detected
Source: Journal of Biological Chemistry
Authors: Margarita Salas, Eladio Viñuela, Alberto Sols
Institution: Consejo Superior de Investigaciones Científicas
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W22204331