Work

Efeito ansiolítico da espermina microinjetada na substância cinzenta periaquedutal dorsal de ratos

Year: 2006

Type: article

Abstract: To investigate a possible effect of the spermine and its polyamins receptors in the dorsal periaqueductal grey (DPAG) in anxiety. Groups of rats received microinjections of spermine (2.5 nmol) into DPAG and were tested in the elevated plus-maze apparatus. Results indicated an overall significant increase in the percentage of entries and in the time spent in open arms. In another experiment the anxiolytic effect obtained after the microinjection of spermine (2.5 nmol) into DPAG was block by previous microinjection of polyamines antagonists, arcaine (4 nmol) or ifenprodil (5 nmol) into the same site. These results indicate that the spermine receptor interaction in the modulation of anxiety in rats exposed to the elevated plus-maze. Considering that polyamines are natural component of the brain, these results suggest that polyamine system within DPAG may play a role in aversion and anxiety

Source: Acta Scientiarum Health Sciences

DOI: 10.4025/actascihealthsci.v28i1.1113

Authors: José Geraldo Pereira da Cruz, Antônio De Pádua Carobrez

Institutions: Universidade Regional de Blumenau, Universidade Federal de Santa Catarina

Language: Portuguese

Topic: Polyamine Metabolism and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2221620140

FWCI:

Cites: 20

Cited by: 2

Related to: 10