Work

Marrow Engraftment by Allogeneic Leukocytes in Lethally Irradiated Dogs

Year: 1967

Type: article

Abstract: Infusion of white blood cells separated from peripheral blood produced allogeneic bone marrow engraftment in lethally irradiated dogs. Approximately 100 x 109 leukocytes obtained from a single donor over an 8-day period were adequate to establish marrow repopulation. Marrow engraftment was indicated by rising blood count, marrow histology, and, in one instance, cytogenetic studies. Marrow grafts were associated with a severe secondary syndrome. Survival was prolonged with methotrexate.

Source: Blood

DOI: 10.1182/blood.v30.6.805.805

Authors: R. STORB, R. B. EPSTEIN, H. RAGDE, J. BRYANT, E. D. THOMAS

Institution: University of Washington

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2241968237