Virtual touch imaging and quantification: a new non-invasive imaging: Method to measure skin stiffness for scleroderma
Year: 2014
Type: conference-paper
Study design: Observational Study
Abstract: Background Skin involvement is of major clinical and prognostic relevance in systemic sclerosis (SSc) and often the primary outcome in clinical trials.Nevertheless, a fully validated objective and sensitive measure of skin involvement is lacking.Virtual Touch Imaging and Quantification (VTIQ) is a new elastography imaging method that provides qualitative and quantitative information about absolute skin stiffness.The objective of this study was to evaluate VTIQ as a potentially method for determining absolute skin stiffness in SSc. 2 Methods Patients 26 consenting patient with confirmed SSc (2013 classification criteria for SSc) underwent clinical and demographic data collection.17 age and gender-matched healthy volunteers were recruited from hospital staff´s and patients' family members.Rodnan skin score (mRSS) Ø Skin thickness measured over 17 anatomical anatomical sites Ultrasound evaluation Ø Absolute skin stiffness (shear wave velocity, (in m/s) was measured at all mRSS anatomical sites using a Siemens ACUSON S3000 TM ultrasound system with a linear 4-9MHz transducer.Sampling gates sized 2x2mm.A greater shear-wave velocity value indicates higher tissue stiffness.Reliability Ø Intra-obsever reliability was assessed by intraclass correlation coefficients (ICC) in 4 SSc patients at all 17 sites and 2 healthy controls, in 2 sequential scanning sessions, one week apart.Statistical analysis Ø Correlations between absolute skin stiffness and mRSS, and comparison between patients and controls were statistically performed using a two-tailed t-tests, in SPSS software.P values <0.05 were considered significant.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2254223045